3.4 Class: Heat shock factors (HSF)
Description: TRANSFAC® class description C0050: Modular structure with an N-terminal DNA binding domain characterized by a central helix-turn-helix motif, an adjacent domain with heptad hydrophobic repeats (HR-A/B) involved in oligomerization, a cluster of basic amino acid residues essential for nuclear import (NLS), and an acidic C-terminal activation domain. (PMID 8689565, PMID 9869631)
Aligned domain sequences: Alignment of HSF DNA-binding domains
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Logo plot:
The missing positions have no recognizable information content, mainly due to extended insertions in some of the aligned sequences.